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MRIs

Last Updated: 2007-03-28 11:59:54 -0400 (Reuters Health)

WASHINGTON (Reuters) - Women with cancer in one breast should get an MRI scan of the other breast to make sure the cancer is not there, too, the American Cancer Society recommended on Wednesday.

Healthy women at high risk of getting breast cancer also should get magnetic resonance imaging scans, the society said.

The recommendations follow a study that shows MRI scans can detect cancer in the opposite breast 90 percent of the time. MRI found breast tumors missed by mammograms, a specialized type of X-ray.

The study, published in The New England Journal of Medicine, involved 1,000 women with cancer in one breast. The MRI scans found 30 out of 33 tumors in the other breast among the women.

"One in ten women diagnosed with cancer in one breast will develop the disease in the opposite breast. Having a better technique to find these cancers as early as possible will increase the chances of successful treatment," said NIH Director Dr. Elias Zerhouni.

The National Cancer Institute, one of the National Institutes of Health, paid for the study.

"This study gives us a clearer indication that if an MRI of the opposite breast is negative, women diagnosed with cancer in only one breast can more confidently opt against having a double, or bilateral, mastectomy," added National Cancer Institute Director Dr. John Niederhuber.

Constantine Gatsonis and colleagues at Brown University in Rhode Island said the study was not designed to find out if MRIs or mammograms are better at finding breast cancer among women who have only an average risk.

"It was designed only to see if MRI improved detection of cancers in the other breasts of women already diagnosed with unilateral breast cancer," she said in a statement.

MAKING SURE

The American Cancer Society said women with a genetic mutation that puts them at high risk of breast cancer, called a BRCA mutation, should also have an MRI scan in addition to annual mammograms.

In addition, women with a close relative with such a mutation should get an MRI, the group recommended.

And women who got radiation treatment to the chest between the ages of 10 and 30, such as for Hodgkin's disease, a lymph cancer, should have MRIs.

Such treatment in the 1970s and 1980s has been shown to raise the risk of breast cancer in later life.

"As with other cancer screening tests, MRI is not perfect and in fact leads to many more false positive results than mammography," noted Dr. Christy Russell of the University of Southern California/Norris Cancer Hospital Lee Breast Center, and chair of the American Cancer Society's Breast Cancer Advisory Group.

"Those false positives, which can lead to a high number of avoidable biopsies, can create fear, anxiety, and adverse health effects, making it imperative to carefully select those women who should be screened using this technology."

Breast cancer will be diagnosed in more than 200,000 U.S. women this year and will kill 40,000, according to the American Cancer Society.

 

New recommendations call for MRI in breast cancer

What breastcancer.org says about this article:

American women know the value of breast cancer early detection from the 25-year-old breast cancer awareness movement. The three major breast cancer screening messages have been told loudly and clearly:

  1. Mammography every year starting at age 40 (but earlier for women with a family history of breast cancer at a young age).
  2. Regular breast examination by your doctor.
  3. Breast self-examination.

But no test or combination of tests is perfect. Even with these three tools, some breast cancers escape detection. Research has shown that between 10% and 15% of breast cancers can be missed even when all three tests are done. Until the breast cancer cure arrives, we need more tools to help detect all breast cancers as early as possible when they are most treatable. Also, women diagnosed with breast cancer in one breast have a higher risk of developing another cancer in the same or the opposite breast. A better approach to detecting a new or existing cancer is hugely important for these women.

The study reviewed here looked at how well breast MRI (magnetic resonance imaging) could detect cancers in the other breast of women just diagnosed with breast cancer. MRI uses magnetic fields to highlight different kinds of tissues, both normal and abnormal. In almost 1,000 women diagnosed with cancer in one breast, an MRI scan was able to detect breast cancer in the other breast of 3% of the women (30 out of 969) that was missed by mammography and clinical examination.

Based on the results of this and another study, the American Cancer Society (ACS) now recommends that women diagnosed with cancer in one breast have an MRI scan of the other breast to make sure there is no cancer there. The ACS also recommends an annual MRI scan for women who are at high risk for breast cancer because they have:

  • a known breast cancer gene (BRCA1 or BRCA2)
  • a first-degree relative (parent, sibling, child) with a BRCA1 or BRCA2 mutation, even if they haven't been tested
  • a lifetime risk of breast cancer score of 20-25% or higher, based on specific risk assessment tools that look at family history and other factors (this can be determined with the help of your doctor)
  • had chest radiation between the ages of 10 and 30
  • certain medical conditions or have a first-degree relative that has them, including Li-Fraumeni syndrome, Cowden syndrome or Bannayan-Riley-Ruvalcaba syndrome

When breast cancer is diagnosed, it's important to carefully evaluate both breasts. You and your doctor may understandably focus only on the breast with the cancer. But knowing what's happening in both breasts (and in your whole body) will help you and your doctors determine the best treatment strategy to get rid of the cancer. Early detection also may help you avoid some treatments that you might otherwise need with a later diagnosis.

It's important to know that MRI is a very sensitive test that can lead to many false alarms. Of the 121 women in this study whose MRI scan showed an abnormality, 30 had cancer; about 25%. That means that about 75% of the women had an MRI abnormality that WASN'T cancer.

The bottom line is that if you've been diagnosed with breast cancer or are at high risk for having breast cancer, an MRI scan is an important additional tool to carefully evaluate both breasts. Information from an MRI scan may help detect breast cancer earlier in high-risk women and may be important in determining the best treatment plan for women already diagnosed with breast cancer. Still, MRI doesn't replace a breast exam by your doctor and mammography. These techniques are important front-line tools for all women.

 

Young women face fertility challenges

 
Simply becoming pregnant after a diagnosis of breast cancer does not appear to increase the risk of breast cancer recurrence. However, because recurrences tend to appear earlier rather than later, oncologists generally advise waiting a minimum of two years, preferably five years, following treatment to become pregnant. >>Read more

Mary's work for young women affected by breast cancer is recognised

Ms Macheras-Magias’, one of the original members of The Young Ones, has been nominated a Pride of Australia Role Model.  Attached is the article which appeared in the Herald Sun.

Mary_HS_300506_Pride_of_Aust_Medal.pdf Mary_HS_300506_Pride_of_Aust_Medal.pdf

Holly's Comic

Survival: A Woman's Tale - by Carol Nader

Kylie Minogue's battle with breast cancer has made headlines around the world. But it is an experience shared by thousands of women in Australia every year.

Rita Marigliani sat numb and alone as her surgeon delivered the shattering news. She went home to her boyfriend and they cried together, then she phoned her two brothers and sister, knowing she had to tell them something they would struggle to digest.

Days later she was lying on a hospital bed recovering from breast cancer surgery. It was Christmas Day 2002. She was 36 years old, the baby of her family, and she had just had her lymph nodes removed.

Instead of a festive lunch at home, her relatives and friends took it in turns to keep her company in a hospital ward. Still, Marigliani decided to look on the bright side - the hospital put on a good spread and she didn't have to wash the dishes.

Despite losing her mother to breast cancer 10 years earlier, and later her father to lung cancer, it did not occur to her that the two lumps she had carried on her left breast for 18 months might one day kill her. She was young and active. She certainly did not feel ill.

The seemingly innocuous lumps lay beside each other, nestled beneath her armpit. Numerous tests and mammograms over several months had given inconclusive results. But with the lumps showing no sign of simply going away, a surgeon decided it was best she have them removed - just in case.

"At this time I thought we were being thorough about something I felt pretty confident was nothing," she recalls.

"Despite all the tests I'd gone through, I was convinced that this wasn't going to be cancer. I was fit and young and that wasn't going to be an outcome.

"But when it was the outcome I was completely shocked and floored and scared. I thought I was going to die."

Apart from the mere act of surviving, she was plagued by other issues - would she still feel desirable?

How would it affect her sexuality? Would she ever be able to have a baby? And would she still want to have sex with her boyfriend?
The good news was the cancer had not spread to her lymph nodes, so statistics were heavily on her side.

"As a young person I thought I was going to die and I wasn't ready," she says. "This wasn't something I was expecting and I didn't know how I could possibly cope with it. I started to then learn more about the disease and what my prognosis would be and started to feel a bit more confident about getting involved with treatment and making decisions about it."

Uncertain and scared, but silently optimistic, she began treatment. First came four lots of chemotherapy, one dose every four weeks over several months. And then she began to lose her hair, an experience that brought home the degree to which her plight would drastically affect her life.

"It was really confronting when I heard I was going to have chemotherapy," she says. "I was very concerned about losing my hair. I wanted to look normal. I didn't want to look or feel different."

The chemotherapy left her with nausea that sometimes lasted for days, and an aversion to food.

Talking to other women in her situation helped to make her feel more normal, and an understanding employer meant she was able to continue working, despite the fatigue and nausea - the inevitable symptoms of chemotherapy. She also completed six weeks of radiotherapy.

While some women's libidos are affected by cancer treatment, Marigliani found herself seeking intimacy. "For me I probably felt the need for intimacy more because it's a time when you need comfort and the idea of trying to keep things normal was important for me as well," she says. "After the surgery you can be sore where you've had surgery and we spoke about physical issues like that, but otherwise things were pretty normal."

Like most of her girlfriends, she had intended to delay having children until she was in her mid to late 30s. She went to see a fertility specialist but decided against freezing her ovarian tissue because it would have meant another operation. Given she was young, she decided to take her chances. She has no reason now to think she can't have a baby.

"At a time when all my friends were putting off having children until mid to late 30s, I was in that category as well - and then to have that decision possibly taken away from me made me angry," she says."

For a young woman to be diagnosed with breast cancer, that's shock enough, and then to have the extra burden of having to make decisions about fertility and sexuality is a lot to have to digest and process at one time."

By late 2003, Marigliani was told that the cancer had been removed and there was no evidence the disease remained. But she will never be declared "cancer-free" and the uncertainty of her situation means even now, having recovered, there is still a thought in the back of her mind that it might come back.

"It's one of those things that can come back even many years after initial diagnosis," she says.

"There's no measure of cancer-freeness. At no stage will I ever hear that news."

As for the scars from her surgery, she considers them "medals" - "almost something to be proud of - that I got through it and I'm here and doing really well".

But she says the experience from the time she was diagnosed made her quickly reorganise her life's priorities. "You realise your family and friends are the most important things in your life and the people you want to spend the most time with," she says.

"There is support and you're not alone."

BREAST CANCER . . . AND HOW THE SURGERY IS PERFORMED

First the bad news: breast cancer is the most common cancer among Australian women, with an average 32 new cases diagnosed each day. It is also the biggest cancer killer, claiming seven women's lives a day.

The good news: survival rates are improving through earlier detection, better treatment and new drugs. And when it comes to "early breast cancer" - cancer contained in the breast that may, or may not, have spread to lymph nodes in the armpit - treatment is generally effective, with 90 per cent of women having no further problem from the cancer in the next decade. Most women diagnosed and treated for early breast cancer do not die from the disease, according to the National Breast Cancer Centre.

WHAT CAUSES BREAST CANCER?
It is not known what causes the disease, although there are factors that increase the risk. Most women with breast cancer, however, have no obvious risk factors. As there is currently no means of preventing breast cancer, the focus in reducing deaths from the disease has been on finding breast cancer as early as possible. The Federal Government offers free mammograms for women aged 50 to 69.

WHAT INCREASES RISK OF CANCER?
Breast cancer is more likely in older women, those with a family history of breast cancer or those previously diagnosed with breast cancer. Among those things to show a slight increase in risk are early menstruation (before 12), late menopause (after 55), being childless or having children after 35, and not breast feeding.

HOW IS IT FOUND?
Breast cancers can be found in several ways, including mammogram screening, discharge or a lump in the breast. If a lump found, those over 35 usually have a mammogram (low-dose X-ray) and those under 35 an ultrasound, or both. If abnormal tissue is found, a sample is taken with a needle, or sometimes under general anaesthetic. The sample is tested by a pathologist. Results can take a few days.

HOW DOES IT DEVELOP?
- Ductal carcinoma in situ is a cancer that is contained in a milk duct in the breast, and has not spread into the breast. It is thought invasive breast cancer starts with DCIS. This type of cancer is usually found by mammograms in older women and cannot be felt as a lump.

Removal with surgery is the usual treatment. As there is no spread, the cancer is effectively cured (although other cancers can be found). About 1200 women are diagnosed with DCIS each year in Australia, most aged 55-59.

- Invasive breast cancer is regarded as a cancer that has spread from the milk duct into the breast. It can be found as a lump. In some cases it is contained in the breast, in other cases the cancer has spread to the lymph nodes in the armpit.

Treatment aims to remove the cancer, destroy cancer cells that may be left in the breast and destroy any cancer cells that may have spread outside the breast and armpit area, but cannot be detected.

WHAT ARE THE TREATMENT OPTIONS?
Each woman's situation is different, and likewise treatment differs. Typically, if a lump is less than three centimetres in diameter, surgeons usually remove the lump and one lymph gland in the armpit.

This is located by injecting a dye into the breast.

The operation is done under general anaesthetic and patients typically stay overnight. If the removed gland - typically the size of a fingertip - is clear of cancer, no further surgery is required. If it is affected, more lymph glands can be removed. Radiotherapy is usually recommended after a lump is removed.

A typical course is every weekday for six weeks. In most cases of early breast cancer, surgery and radiotherapy is regarded as being as effective as a mastectomy, or removal of the breast.

A mastectomy is considered an option if the cancer is large compared with breast size, the cancer is in more than one area in the breast, or previous surgery has failed to remove all the cancer.

In some cases women are given hormone treatment, such as the drug tamoxifen. This depends on the type of cancer found. If the cancer is thought to have spread from the breast and armpit area, chemotherapy can be given. - Tom Noble

Published in The Age – May 19 2005

Photo: Paul Harris

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